Dog Genetics: Nutrigenomics and the Power of Epigenetics

Inheritance and Environment

An easy way to understand dog DNA is to think of it as a blueprint for your dog's body, predicting not only physical traits but behavioural ones as well. Historically speaking, most people believed that genes dictated an unavoidable future — if you had a genetic marker for disease, then you would get that disease. What we now know, however, is that even if a blueprint codes for a condition, that doesn't necessarily mean that your dog will develop that condition.

In other words, your dog's DNA does not dictate his destiny. Discover magazine explains that the reason for this is a network of other factors, called epigenetics, that influences how genes behave and express (turn on and off) without changing their physical makeup. Epigenetics encompasses both inherited expression factors and environmental influences.

The Power of Epigenetics

Scientists now understand that environmental factors such as stress, infection, nutrition, and exercise are more important than previously thought in controlling what genes are expressed. Additionally, your pet's microbiome, tiny microbes living in and on your pet, are much more important than previously thought and are just now starting to be understood. In humans, these factors can even impact future generations. A Swedish study in the European Journal of Human Genetics found that the grandsons of men who lived during a period of plentiful food as children were more likely to develop diabetes and heart disease from overeating!

Like humans, a dog's individual lifestyle and environment directly interact with their DNA to influence either positive or negative epigenetic changes. Even if your dog has the perfect genetic blueprint, factors that influence epigenetics, such as a sedentary lifestyle or poor nutrition can erode the foundation of his health. Conversely, keeping your pup as healthy as possible might help lower his risk of developing a problem his breed is predisposed to.

Nutrigenomics: Nutrition + Genetics

The old adage holds true for us and our pets: you are what you eat. Nutrition is a powerful driver of epigenetic modifications that influences your dog's DNA. Different ingredients and nutrients have the ability to influence a gene's activity or expression, and can even change how genetic disease manifests. The study of the effect of nutrition on the genome is known as nutrigenomics. Current science can't provide your vet with a magic formula for good health, but it's an exciting new frontier in preventive medicine for our pets.

How can you benefit your dog's genetic health? Do what you can to positively influence epigenetic factors: reduce your dog's stress, give him plenty of exercise and feed him healthy food. Choosing healthy, research-based pet food that has been comprehensively studied and proven to benefit your dog's biology is a great first step. You may not be able to change his inherited blueprint, but a little knowledge of genetics can help you keep your dog happy and healthy.